Introduction:¶
- The ‘syntax approach’ is an attempt to describe the locomotion of C. Elegans in terms of a vocabulary of ‘worm shapes’. 90 distinct postures are sufficient to account for 82% of postural variance.
- This enables the use of methods developed for other kinds of discrete data in bioinformatics and language processing to be harnessed for the study of behavior.
- The tools contained in the behavioral_syntax module are designed for desktop usage and it’s assumed that the data will be stored using a file system, not a database.
road map:¶
- Build tools for analysis of discrete sequences(n-gram models, grammar inference algorithms…)
- Analyse the effectiveness of these tools for phentoyping C. Elegans behavior.
- Use effective tools for building phenotype classification algorithms.
list of supporting papers:¶
1. This is hard to summarize, but if I had to choose just one paper to read I would settle for the original Behavioral Syntax paper: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004322